01/

The effects of Ojeok-san on neuroscience-immune interactions in cancer-induced visceral pain

02/

Development of dietary quercetin to treat muscle wasting disorders

03/

Characterization of spontaneous pain in colorectal cancer

04/

Effects of ojeok-san on pain-like behaviors in a mouse model of colitis

05/

Silybin as an anti-inflammatory and anti-fibrotic agent in cancer cachexia

06/

Skeletal muscle macrophage manipulation in a model of cancer cachexia

Current Research Projects

The central hypothesis is that Ojeok-san attenuates cancer induced visceral pain by polarizing macrophages to an anti-inflammatory phenotype and decreasing TNFalpha (Patrice Cunningham, Aman Sumal, and Gustavo Martínez-Muñiz). NIH-K99/R00, K. Velazquez 

In this Phase I SBIR project we will test the hypothesis that dietary quercetin will ameliorate the cancer and chemotherapy-induced cachexia and thereby result in improved therapeutic outcomes (Patrice Cunningham). NIH-R43, K Velazquez and B VanderVeen 

The goal of this project is to measure spontaneous pain in animal models of colorectal cancer using telemetric technology together with behavioral and metabolic cages of Promethion Sables System. SSMN-Seed Grant, K Velazquez 

The goal of this Magellan Scholar Program (Emma Patton) proposal is to determine whether Ojeok-san can be used as a therapy to treat mechanical referred hyperalgesia in colitis and to determine if these effects are mediated via TNF alpha.

The goal of this research proposal is to test the hypothesis that silybin attenuates skeletal muscle fibrosis and impaired function through TGF-beta signaling. NIGMS/NIH P20GM103641

Our lab wants to better understand how cancer promotes cachexia and how to develop novel therapies that may ultimately improve skeletal muscle function. RDA-VA