01/

The effects of Ojeok-san on neuroscience-immune interactions in cancer-induced visceral pain

02/

Development of dietary quercetin to treat muscle wasting disorders

03/

 Characterization of spontaneous pain in colorectal cancer

04/

Effects of ojeok-san on pain-like behaviors in a mouse model of colitis

05/

Involvement of macrophage-produced tumor necrosis factor alpha on tumor burden in a mouse of colorectal cancer 

06/

Characterization of spontaneous pain in colitis

Current Research Projects

The central hypothesis is that Ojeok-san attenuates cancer induced visceral pain by polarizing macrophages to an anti-inflammatory phenotype and decreasing TNFalpha (Patrice Cunningham, Aman Sumal, and Gustavo Martínez-Muñiz). NIH-K99/R00, K. Velazquez 

In this Phase I SBIR project we will test the hypothesis that dietary quercetin will ameliorate the cancer and chemotherapy-induced cachexia and thereby result in improved therapeutic outcomes (Patrice Cunningham). NIH-R43, K Velazquez and B VanderVeen 

The goal of this project is to measure spontaneous pain in animal models of colorectal cancer using telemetric technology together with behavioral and metabolic cages of Promethion Sables System. SSMN-Seed Grant, K Velazquez 

The goal of this Magellan Scholar Program (Emma Patton) proposal is to determine whether Ojeok-san can be used as a therapy to treat mechanical referred hyperalgesia in colitis and to determine if these effects are mediated via TNF alpha.

The goal of this Magellan Scholar Program proposal (Yvone Shametaj & Nour Shams) is to identify the role that TNF alpha plays in colorectal cancer. Our objective is to determine if inhibiting macrophage-produced TNF alpha hinders carcinogenesis.

In this SURF and Exploration grant (Matthew Noneman) we will test the hypothesis that spontaneous visceral pain can be detected using behavioral and metabolic phenotypic cages with telemetry technology.